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Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)

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Published laboratory studies have examined 5-Amino-1MQ as an NNMT inhibitor in experimental models

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References: Andres, E., Loukili, N

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