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This imbalance causes overactivity of the indirect pathway and a reduction in the activity of the direct pathway, leading to typical motor symptoms such as tremors, rigidity, and bradykinesia

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These receptors are of two kinds: ionotropic or metabotropic (mGluRs)

Second, in PD, the abnormal aggregation of alpha-synuclein may increase excitotoxicity by affecting the transport efficiency of glutamate transporters and increasing the phosphorylation of NMDARs

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