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Research demonstrates that TB-500 administration mobilizes EPCs from bone marrow reservoirs, with animal studies showing 3-fold increases in circulating EPC numbers that contribute to neovascularization through both structural incorporation into developing vessels and paracrine secretion of pro-angiogenic factors

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This switch in cell fate may be advantageous in tissues with limited replicative potential, like neurons in the brain and myocytes of the heart

It also acts as a cofactor and regenerator for other antioxidants directly reducing oxidised vitamin C and vitamin E back to their active forms, effectively amplifying the antioxidant capacity of the entire system

Devaraju P, Yu J, Eddins D, Mellado-Lagarde MM, Earls LR, Westmoreland JJ, et al