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exclusion criteria were (1) in vitro models, and (2) studies published in non-English language journals

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Similar promoter methylation events have been described in other cancers, including the extracellular regulation genes (WIF1), Dickkopf Wnt Signaling Pathway Inhibitor (DKK1-3), SFRP1, 2, 4, and 5) and intracellular regulatory genes (DACT1-3, Axin, APC)

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This can be countered by following a programme consisting of an anti-inflammatory diet and cosmeceuticals