Per-mg normalization is computed as price_cents (mg_per_vial vial_count) so a 10-vial bundle of 5mg vials at $400 normalizes to the same $8.00/mg as a single 10mg vial at $80
From this equation, it can be seen that local anesthetics will be ionized (BH + ) and therefore hydrophilic (not lipid soluble) in an acid environment
Water, Polysorbate 60, Palmitic Acid, Butylene Glycol, Propylene Glycol, Mineral Oil, Sorbitan Stearate, Isopropyl Palmitate, Dimethicone, Cetyl Alcohol, Stearic Acid, Tocopheryl Acetate, Glutathione, Arbutin, Acetyl Tyrosine, Saxifraga Sarmentosa Extract, Paeonia Suffruticosa Root Extract, Schizandra Chinensis Fruit Extract, Lilium Candidum Flower Extract, Aminopropyl Ascorbyl Phosphate, Scutellaria Baicalensis Root Extract, Carbomer, Glycol Cetearate, Acetyl Hexapeptide-8, Saccharomyces Extract, Glycol Stearate, Ethylhexyl Methoxycinnamate, Butyl Methoxydibenzoylmethane, Titanium Dioxide (CI 77891), PPG-20 Methyl Glucose Ether, Citric Acid, Disodium EDTA, Sodium Sulfite, Sorbitol, Methylparaben, Ethylparaben, Propylparaben, Butylparaben, Isobutylparaben, Phenoxyethanol, Sodium Hydroxide, Methylisothiazolinone, Fragrance
Using HSCs, Bates and colleagues investigated the role of ACC in liver fibrosis (220)
Interestingly, our lab recently identified the widely clinically used anti-depressant sertraline as a potent SHMT inhibitor that selectively inhibits proliferation of serine synthesis addicted cancer cells (8)
10.1016/j.theriogenology.2020.08.034 44
