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Using a 2-D cell culture format with monolayer Caco-2 cells, for example, it is not possible to reproduce the physiological conditions present in the intestines, such as the unique intestinal tissue morphology of villi formation and mucus production, as well as key intestinal differentiated functions including cytochrome P-450-based drug metabolism

Ryter, S

Patients with this syndrome may also have microcephaly and motor difficulties

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FIGURE 2 3 Other strategies for improving hypoxia 3.1 Small engine, big impact: how erythrocytes maintain energy and redox balance without organelles Erythrocyte metabolism has long been considered straightforward, relying almost exclusively on glucose breakdown via glycolysis and the PPP