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1 Introduction Chimeric antigen receptor T (CAR-T) cell therapy is a pivotal innovation in the field of targeted immunotherapy, allowing for the direct recognition of tumor-associated antigens (TAAs) without requiring major histocompatibility complex (MHC)-mediated antigen presentation ( SLE is a severe autoimmune disorder, affecting primarily women of childbearing age with a prevalence of 0.1% in the general population ( With the advancement of innovative immunotherapies, CAR T-cell therapy holds great potential for treating patients with refractory SLE ( + B cells or BCMA + plasma cells or double-positive plasmablasts ( Taken together, this review aims to evaluate the potential of CAR-T cell therapy in treating SLE\-related diseases

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