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Cochrane Database Syst Rev 11:CD006271 Niedringhaus M, Jackson PG, Evans SR, Verbalis JG, Gillis RA, Sahibzada N (2008) Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone

The labeled starting dose is 0.25 mg weekly for four weeks

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Prolonged continuous use without an off period raises a theoretical risk of copper accumulation

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