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Effect of methionine restriction on bone density and NK cell activity

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doi: 10.1080/10942912.2020.1866597 100 MarikPE

S., Kalampokas, E

To put it simply: Collagen builds the house, but glutathione stops it from burning down

GSH biosynthesis occurs exclusively in the cytosol via a two-step ATP-dependent reaction catalysed sequentially by two enzymes: gamma-glutamylcysteine synthetase (GCL also referred to as gamma-glutamylcysteine ligase, comprising the catalytic GCLC subunit and regulatory GCLM subunit), which catalyses the rate-limiting first step of joining glutamate and cysteine