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The LD control group was particularly distinct from the other groups in the unweighted UniFrac and BrayCurtis dissimilarity analyses plots, suggesting that animals exposed to the same diet at an early age in life diet develop similar microbiome profiles that persist even after an acute change in diet

In theory, combining agents that both reduce adiposity and improve insulin sensitivity could produce additive or synergistic metabolic effects but this is entirely speculative and unproven in humans

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