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The growth-promoting and angiogenic properties of the compound make its use in pregnancy particularly concerning: aberrant angiogenesis during placental development is associated with preeclampsia and fetal growth disorders
It is a well-established model for osteoarthritis, especially in cohorts of older age than we used here (52w) (Botter et al., 2011) and for the unhealthy loss in muscle (sarcopenia) and fat mass(Wijnhoven et al., 2005)
