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Wilson E, Knudson W, Newell-Litwa K

Integrated Metabolic Axis Beyond its direct actions on skeletal muscle, AX also exerts systemic regulatory effects along the liveradipose tissuemuscle axis, with the liver acting as a central metabolic hub of energy redistribution and lipid handling across peripheral tissues [77]

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Adults and adolescents weighing at least 50 kg must not exceed 4,000 mg per day to avoid liver damage

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Infiltrative disorders such as amyloidosis, sarcoidosis, or lymphoma may produce a markedly increased ALP level with a normal bilirubin concentration