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This interaction site is less defined but comprises the glutathione moiety of Grx(SSG), parts of helix 3, and a conserved lysine/arginine residue that also contributes to the scaffold site 14,15

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91 In addition, lactylation at K91 of TFEB inhibits its interaction with the E3 ubiquitin ligase WWP2, leading to reduced ubiquitination and proteasomal degradation of TFEB, thereby resulting in enhanced TFEB activity

Key additional potential side effects: Hypersensitivity reaction

Your bariatric surgery teamincluding your surgeon, dietitian, and potentially an endocrinologist or obesity medicine specialistmust be involved in this decision-making process