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Cell 182 , 625-640 e624

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Small-molecule inhibitors such as quinoline-5-sulfonamides norfloxacin analogs, and zelkovamycin analogs possess anticancer and antibacterial activities (Zieba et al., 2024

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2) NLRP3 inflammasome activation, triggered by Tat, gp120, and viral RNAs, which is exacerbated by ROS, ion flux changes, and impaired autophagy, with NF-B acting as a crucial priming signal for pyroptosis and pro-inflammatory cytokine release