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Elevated Production Levels Of Gastric Acid Gastric acid production is increased by nicotine in stomachs although necessary for digestion, but excessive levels may cause discomfort through conditions such as heartburn, acid reflux, and even ulcers, since this extra amount irritates the lining around the individuals esophagus and inside the belly thus resulting into long term problems with digestion if they keep taking nicotinic substances

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In addition, smoking increases the production of pro-inflammatory cytokines (IL-1, IL-6, and TNF-) involved in liver cell injury

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