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Circulation 94(1):1925 Rodgman A, Perfetti TA (2013) The chemical components of tobacco and tobacco smoke, 2nd edn Sanchez A et al (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors