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Gene expression in AP/NTS and ARC after 3 weeks of treatment Following the 21 days of treatment, the DVC, LPBN and MBH were punched, mRNA extracted to identify global patterns of differential gene expression using bulk RNA-seq
Which should I start with
doi:10.1016/S0736-0266(03)00110-4 Cerovecki T, Bojanic I, Brcic L, et al
But thats the wrong way of looking at things
One of the most significant of these is the activation of SIRT1, often called a longevity gene. SIRT1 helps manage insulin sensitivity and supports healthier blood sugar regulation, which is fundamental for sustained energy and preventing the metabolic strain that can lead to weight gain
NMDA receptors requirement for coincidence detection to activate and ability to flux calcium ions makes the NMDA receptor integral to synaptic plasticity, and NO co-transmission is intimately coupled to NMDA receptor activity in this context (Hansen et al., 2017)
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