Accumulation of Langerhans' cells on the epithelial surface of the lower respiratory tract in normal subjects in association with cigarette smoking
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Statistical analysis Subjects were assigned to the PK population set (PK set) if they completed the use of the study product, had data for the critical time points in the plasma nicotine concentrationtime profiles, did not use a concomitant medication that rendered the concentration profile unreliable, and did not violate the protocol (major protocol deviation) in a way that might invalidate or bias the PK results
