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Due to the generally low intake of B12, supplement dosages must be significantly higher thus the daily requirement is covered only with supplements of approx

To carry out the experiment based on the simultaneous reduction and derivatization reactions the set of samples were prepared as follow

Spindler SR (2006) Use of microarray biomarkers to identify longevity therapeutics

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Final research-target dose 2.4 mg + 2.4 mg weekly Titration length ~16 weeks Trial duration 68 weeks (REDEFINE 1 / REDEFINE 2) Route Subcutaneous, once weekly Compound Delivery: 2.4 mg / 2.4 mg Maintenance Pre-blended vials simplify weekly administration to a single injection but lock the ratio at 1:1