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In vitro experiments have shown that tobacco smoke extract activates the MAPK/AP-1 signaling pathway and promotes aberrant proliferation of urothelial cells 23 , while nicotine contributes to tumor progression and chemoresistance through activation of the PI3K/AKT/mTOR signaling axis 24

Eberhard, T., Casillas, G., Zarus, G

I never saw him use the music room downstairs, a vast marble pavilion with pianos, organs, and horns

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[DOI] [PubMed] [Google Scholar] [116].Dalle-Donne I, Colombo G, Gornati R, Garavaglia ML, Portinaro N, Giustarini D, Bernardini G, Rossi R, Milzani A, Protein Carbonylation in Human Smokers and Mammalian Models of Exposure to Cigarette Smoke: Focus on Redox Proteomic Studies, Antioxidants & redox signaling, 26 (2017) 406426