The data herein suggests that GPx1 deficiency could underlie the increased susceptibility of macrophages from patients with active CD for increased H 2 O 2 -cytotixicity
Metabolic reprogramming and polarization of microglia in Parkinson's disease: role of inflammasome and iron
Depletion of glutathione affects root development also by interfering with auxin transport 84,89,90
Here we investigated the potential interactions between APR-246/MQ and Trx1 and Grx1, and found that reaction of MQ with both Trx1 and Grx1 was associated with loss of free thiols in both proteins
Research in cardiac ischemia models showed that TB-500 reduced pro-inflammatory cytokines (TNF-alpha, IL-1beta) at injury sites, potentially creating a less hostile environment for repair cells to operate in. Think of TB-500 as upgrading the cellular infrastructure giving repair cells the physical capacity to do their job
doi: 10.1371/journal.pone.0205708, 69
