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Concious of his parsimonious and taciturn persona, "Silent Cal" manipulated situations with dramatically punctuated use of his cigar

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In high-risk individuals, cannabis can disrupt brain development and lead to conditions like schizophreniaa severe mental illness characterized by long-term hallucinations, delusions, and paranoia

Finally, ACh activation of nAChRs may disrupt the maturational cadence of the GABA system [79]