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[47] A true breakthrough came in 1948, when the British physiologist Richard Doll published the first major studies that proved that smoking could cause serious health damage

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Fact : Not all of the harmful chemicals created during cigarette manufacturing are man-made

Proctor (December 1996), "The anti-tobacco campaign of the Nazis: a little known aspect of public health in Germany, 193345", British Medical Journal , 313 (7070): 14501453, doi:10.1136/bmj.313.7070.1450, PMC 2352989, PMID 8973234 "Research on Smoking and Lung Cancer: A Landmark in the History of Chronic Disease Epidemiology"