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Cancer Causes Control 13:8390 Zhang Q, Tang X, Zhang ZF, Velikina R, Shi S, Le AD (2007) Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways

Hawaii and California have raised the tobacco purchase age to 21 statewide

Smell alone doesn't tell you everything though

Smokers are twice as likely to die before age 65 and every cigarette smoked reduces a smokers life expectancy by 20 minutes

Some smokers already have been using fire-safe cigarettes without even knowing it

The program also targets smokeless tobacco, which is more widely used in some rural areas