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As well as those 150 mutations found in the lungs, scientists found that a pack-a-day habit for a year produced an average 97 mutations in each cell in the larynx (voice box), 39 mutations in the pharynx (top part of the throat), 23 in the mouth, 18 in the bladder and six in the liver
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As the outgrowth number increased, the expression of P/S cell markers (CK5, CK14 and p63) in the BEC cultures and explants significantly decreased in both smokers and COPD patients, and this was most prominent in patients with COPD
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