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Both showed a potential benefit for smoking cessation and high levels of continued e-cigarette use at the end of the intervention, but presented no long-term safety data, which aligns with the findings of our analysis.104 , 105 The patient engagement activities undertaken for this guideline to assess patient preferences included 19 individuals in phase 1 and 8 in phase 2, and were limited in terms of diversity, so may not be generalizable to the broader population
Researchers are a little conflicted in just how much nicotine makes it into the blood stream of a smoker, but estimates generally fall in the region of 1mg - 2mg per cigarette [2] [3]
Densities in this range are substantially higher than the average density of the nonstripped smoke particles (990 94 kg m 3 ), and are common for many higher-molecular weight organics 41
