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Most people who smoke don't continue to do so out of choice its because they have a nicotine addiction

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J Biol Chem (2001) 276(7):458896

This has led to the hypothesis that the increased tissue Cu may increase the activity of the enzyme lysyl oxidase, which is a Cu-dependent enzyme that has been implicated in the pathogenesis of several fibrotic disorders, including OSF [24]

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