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"Nicotine poisoning occurs when nicotine begins to exhibit more dire toxic effects on an individual." The Centers for Disease Control and Prevention (CDC) warns that 50 to 60 milligrams of nicotine is a deadly dose for an adult who weighs about 150 pounds

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In addition to usage time, the actual nicotine blood plasma concentration will be influenced by various factors, including the nicotine content of the product, the amount of nicotine extracted during use, average daily consumption (ADC), use behaviour and individual metabolism

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