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ISBN 978-1574413083.

Introduction Sickle cell disease (SCD) is a genetic disorder that disproportionally affects people of African descent ( Intravascular hemolysis, a critical contributor to vaso-occlusive crises---the principal pathological manifestation of SCD---refers to the destruction of red blood cells (RBCs) within the blood vessels (Van Avondt et al., 2019)

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