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A broad range of different immobilization methods is applied, ranging from protein adsorption, covalent coupling, entrapment and encapsulation to intermolecular cross-linking with filler components, specific high-affinity docking and combinations thereof [142-144]

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A dose-related increased incidence of mononuclear cell leukaemia was found in both sexes, significant at the 2 highest exposures in females, from the 18th or 19th month onwards

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