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Consequently, when these mice were challenged with non-typeable Haemophilus influenzae infection, they showed delayed bacterial clearance compared to air controls(46) Similarly, in human subjects infected with live-attenuated influenza virus (LAIV), nasal anti-LAIV IgA levels were decreased in e-cigarette users when compared to nonsmoking/non-vaping controls after LAIV inoculation(78) (Figure 6)

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