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Patients report improved energy, better body composition over time, and in some cases improved metabolic markers

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However, in the blood of ME/CFS patients, excessive oxidative stress response to exercise can be measured via different plasma markers (192), and in mitochondria from ME/CFS patients, defects have been detected in CoQ10 and in Complex V (aka ATP synthase) (182, 190)

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Conversely, TFL concentrates exclusively on fertility loss