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Evidence Supporting the Gateway Hypothesis The strongest evidence in favor of gateway drug theory includes: Kandels pioneering longitudinal research, initiated in 1975 and replicated across multiple cohorts, consistently documented a statistically significant sequential pattern in which adolescents who used one substance category were substantially more likely to advance to the next in a predictable progression from licit to illicit substances

Estrogen metabolites linked to breast, ovarian, and prostate cancer: For breast cancer , the 4-OHE1(E2) and 16-OHE 1 metabolites are implicated in increasing the relative risk of cancer

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Another plaintiff, David Masessa of Chatham, N.J., began using Juul in 2015 in an effort to stop smoking cigarettes

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