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Abbreviations CI: Confidence intervals DALYs: Disability-adjusted life years DHS: Demographic and Health Surveys GATS: Global Adult Tobacco Survey ICS: Individual Country Survey PAF: Population attributable fraction SEBS: Special Europe Barometer Survey ST: Smokeless tobacco STEPS: STEPwise Approach to Surveillance TSNA: Tobacco-specific nitrosamines WHO: World Health Organization References National Cancer Institute and Centers for Disease Control and Prevention

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Thus, we used the methylated genes from blood samples more extensively for pathway-based analysis and used the methylated genes from buccal samples only for replication

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