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The fact that the in vivo toxicology studies [18] were conducted at matched levels of TPM for the smoke from all cigarettes (to hold TPM constant) also meant, as PM scientist Reininghaus noted internally in 1998 [96], that the rats breathing the smoke from the cigarettes with the additives were exposed to lower levels of toxins in the smoke than if the exposures had been matched on another smoke variable, such as nicotine delivery

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