The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract
Because of the potential drawback of IV administration in these situations, clinicians and parents might want to consider oral glutathione supplement instead
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By taking the time to carefully evaluate your options, you can find a peptide supplement that aligns with your goals and helps you achieve the muscle growth youre working towards
& Cripps, A
