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For many people, the obvious way to quit smoking is to cut down gradually until they stop, said lead author Nicola Lindson-Hawley, a post-doctoral researcher at the University of Oxford in the UK

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Material and methods Cell culture Human RPE cells (ARPE-19, CRL-2302, American Type Culture Collection, Manassas, VA

Availability of data and materials Dataset analyzed during the current study is publicly available at the Surveillance, Epidemiology and End Results Program (SEER) repository, Abbreviations PCP: U.S

Senescence -galactosidase (SA--gal), which is overexpressed in senescent cells, is widely used as a marker of cell senescence