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Research using salivary cotinine a nicotine metabolite found measurable nicotine exposure in regular blunt users who reported no tobacco use

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The Effects of Arsenic on Ionic Channel Function as a Mechanism for Arsenic-Induced Metabolic Alterations Ionic channels are complex transmembrane macromolecules forming aqueous pores, which once activated constitute selective functional pathways for ions to move through by diffusion down their electrochemical gradients (206)

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