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FASEB J 29(7):29122929 Wiegman CH, Michaeloudes C, Haji G, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM, Copdmap (2015) Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

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Also, by the 1880s, cigarette production had been mechanized with the advent of the Bonsack machine, which made it possible to produce additional units for little or no additional cost, and the prices of cigarettes were cut in half (Chaloupka et al