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Indigenous to the reefs of the Indo-Pacific, geographic cones grow to about 6 inches (15 centimeters) in length and have intricately patterned brown-and-white shells are among the most sought after by collectors

Sometimes a liver biopsy may have to be performed for confirmation of liver damage

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COX2 can increase hepatic inflammation and promote collagen and TGF-1 expression of hepatic stellate cells 62 , and also can prevent abnormal differentiation of HBV-infected hepatocyte apoptosis by COX2/Wnt/catenin pathway 63