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It is well-established that drugs of abuse hijack the midbrain dopamine reward pathway, induce excessive release of dopamine and cause long-term adaptations of neural circuits, which finally leads to addiction 5,7

E-cigarettes are thought to be a less harmful alternative to tobacco cigarettes

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They still deliver nicotine but with less of the harmful chemicals found in conventional cigarettes

Additionally, OAT4 participates in the transport of high-affinity binding steroids such as estrone sulfate (ES)

Dogs are especially at risk when they consume THC-infused edibles such as gummies or chocolates