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In 7 studies being a smoker was only asked and answered with a yes/no question [35, 38, 40, 41, 45, 50, 54]

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While the relationship between gateway drugs and substance abuse is complex, research indicates that early exposure to these substances can have a significant impact on an individual's susceptibility to addiction and subsequent substance abuse

Trazodone has become an extremely common off-label treatment for insomnia, including in people with AUD and OUD

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