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Approved pharmacological interventions include a variety of nicotine replacement therapies (gum, lozenge, patch, nasal spray and oral inhaler) with effect sizes of 1.60 (1.53, 1.68) as compared to placebo at 6-months follow-up (Stead et al., 2012), the atypical antidepressant bupropion (effect size 1.69 [1.53, 1.85] when compared to placebo with follow-up at 6-months (Hughes et al., 2007)), and varenicline (effect size 2.27 [2.02, 2.55] compared to placebo at 6-months follow-up [Cahill et al., 2012])

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These symbols often come from classical Chinese values such as harmony, fortune, unity, and balance

Contrasting Replacement Character: The Multiplayer mode focuses away from The Dealer and prospective human players in the upper levels of the club, and instead shows a game hosted by "High Rollers" that are all floating heads with hands like The Dealer (and possibly one humanoid) in the basement level