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This approach utilizes genetic variants as instrumental variables, effectively mitigating confounding biases and reverse causation inherent in conventional observational studies

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While decades of research has shown the detrimental affects of tobacco and flavored tobacco products, the tobacco industry has used every play in the disinformation playbook to bury or manipulate the science to prevent regulations from moving forward

Conversely, a higher cut-off value increases specificity but reduces sensitivity, meaning some irregular light smokers could test negative

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