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CRD42023385632) ( We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, adhering to the 4-phase flow diagram and the 27-item checklist for this study (see PRISMA reporting checklist) 6

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Flavoured Blends Due to the UKs restriction (now lifted) on using most flavourings, these tobaccos are widespread all over the world and like unflavoured tobaccos there are many styles

Placed in a separate room, the glass chamber was equipped with rubber gloves

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Portable cigarette lighter receptacles attached to cables and alligator clips for connection directly to car batteries are available for temporary use