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We noted that we would determine whether such external changes impede the effective measurement of cost by considering factors including: The extent and duration of the changes, and the conceptual and empirically tested relationship between the changes and each measure's ability to accurately capture clinician cost performance (86 FR 65508)

DISCUSSION In this study, we identify MKK3 as a key factor associated with cigarette smoke-induced disruption of mitochondrial quality control in airway epithelial cells

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Herzog said she expects other cigarette manufacturers to follow this price increase