As the hair shaft primarily comprises keratin, enriched in cysteine, we postulate that these trichoscopic signs might be manifestations of localized reduction or metabolic disturbances of cysteine in keratin
Previous reports have noted that SIRT1 transcription is regulated by p53, Foxo3a, and C/EBP [44, 45]
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Every 4 weeks for the first 12 weeks, then every 12 weeks thereafter
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