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Mark Eisenberg, McGill University

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While there is some topical effect with both product types, with the first few layers of skin absorbing some cannabinoids, the deeper systemic effect is unknown and variable

One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30