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In colon adenocarcinoma cells, NNK increases nuclear factor-kappa B (NF- B) affinity as well as the cancer-promoting homomeric nicotinic acetylcholine receptor (nAChR), 7-nAChR

This cycle of using tobacco to manage stress quickly leads to addiction, as the body begins to crave nicotine to maintain these pleasurable sensations

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After this process, cigarettes are packaged in small paper or cardboard boxes, where they sit idly at convenience stores and then into a consumers hand

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