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Notably, while the 2D model primarily exhibited oxidative stress-associated signatures (SBS3, SBS5 and SBS18), the organoid system showed a shift toward the smoking-related SBS4 signature

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Annually, approximately 8 million deaths are attributed to smoking, including 1.3 million from secondhand smoke 9

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Now, of course, Roseanne is even badder in real life than on-screen

It contains items that uniquely cover all sides of the tobacco issue and in turn demonstrate the historically ironic relationship between the medical profession and the tobacco industry